Products & Applications
Genetic Signatures has developed the following product portfolios:
“Molecular diagnostics of infectious diseases, in particular, nucleic-acid-based methods, are the fastest growing field in clinical laboratory diagnostics. These applications are stepwise replacing or complementing culture-based, biochemical, and immunological assays in microbiology laboratories. The first-generation nucleic acid assays were monoparametric such as conventional tests, determining only a single parameter. Improvements and new approaches in technology now open the possibility for the development of multiparameter assays using microarrays, multiplex nucleic acid amplification techniques, or mass spectrometry, while the introduction of closed-tube systems has resulted in rapid microbial diagnostics with a subsequently reduced contamination risk.” 
Genetic Signatures is transforming molecular diagnostics via streamlined sample processing methods linked to highly multiplexed real-time PCR screening assays. The EasyScreen™ Detection Kits simultaneously detect a larger number of pathogen targets in a shorter time than conventional methods. Our single universal sample preparation method is suitable for bacterial, protozoan or viral (DNA & RNA) targets and is automatable via the GS1 automation platform or the most common commercial extraction platforms. Our protocols are compatible with all major real-time PCR instruments. Moreover, each kit comes complete with extraction and internal controls to measure sample integrity, correct sample processing, and PCR inhibition.
Our scientists are pioneers of the bisulphite method used for distinguishing methylated cytosine residues from unmethylated cytosine residues in nucleic acids. The original bisulphite method has since been substantially improved and has led to the development and release of the MethylEasy™DNA bisulphite modification product range.
DNA methylation, together with covalent modification of histones, is thought to alter chromatin density and accessibility of the DNA to cellular machinery, thereby modulating the transcriptional potential of the underlying DNA sequence . Since methylation of cytosines is an important determinant of whether or not any gene is active or inactive, this technology is also of growing importance in screening for diseases with a complex genetic component such as cancer, embryonic development and in stem cell technology. Access to tools such as the MethylEasy™ kits for the analysis of methylation patterns in genes remains important as scientists continue to endeavor to understand these genetic processes.
 Weile J, Knabbe C. Current applications and future trends of molecular diagnostics in clinical bacteriology. Anal Bioanal Chem. 2009 Jun;394(3):731-42
 Cedar H, Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 2009;10:295–304. [PubMed: 19308066]